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WPF and .Net 4.5 Issues

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I have an application that i have developed in .net 4.0 and on app startup i make a few database calls and bind my results to a couple different datagrids on different tabs in my main view.  On my machine i get the results back in a couple seconds and I can click on the various tabs and see my results in the various grids just fine.  A couple users have updated to .net 4.5 and they are seeing some very bad performance suddenly.  The initial database calls are taking more than a couple seconds, they are taking a couple minutes.  And after the db calls finish I bind my results to the grids but when they try click on another tab to view the different grids they are getting a not responding message and the entire app gets disabled for a minute or two before the tab change gets processed.  I myself am not firing off any code or any db calls on tab changes, all the data should have already been pulled back and bound to the various grids/controls on each tab.  It's like WPF and the notifypropertychanged stuff is the culprit and very laggy with the .net 4.5 update.  If I try to reproduce on my machine it works great but I haven't updated to .net 4.5 yet.  Anyone experienced this before or have any ideas as to what's happening?

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